JZL 184

Name	JZL 184
Synonyms	JZL 184 JZL-184 JZL 184 JZL 184 JZL184 JZL-184 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184
CAS	1101854-58-3

Molecular Formula	C27H24N2O9
Molar Mass	520.49
Density	1.467±0.06 g/cm3(Predicted)
Melting Point	116-120°C
Boling Point	706.4±60.0 °C(Predicted)
Solubility	DMSO: ≥ 35 mg/mL
Appearance	White to off-white solid
Color	light yellow to yellow-green
pKa	13.32±0.29(Predicted)
Storage Condition	2-8°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
In vitro study	JZL184 is a useful tool for studying the role of endogenous 2-AG signaling. JZL184 time-dependently inhibited MAGL with a selectivity of more than 300 times that of FAAH. JZL184 does not interact with CB1 or CB2 receptors and does not inhibit the biosynthetic enzymes diacylglycerol lipase-α and diacylglycerol lipase-β of 2-AG, or arachidonic acid mobilization enzyme cytoplasmic phospholipase A2 group IVA.
In vivo study	JZL184 rapidly and consistently inhibits mouse brain 2-AG hydrolase activity, resulting in an 8-fold increase in endogenous 2-AG levels that is maintained for at least 8 hours. Jzl184treated mice showed a wide range of cb1-dependent behavioral effects, including analgesia, hypokinematics and hypothermia, that is, a broad role for 2-AG-mediated endocannabinoid signaling throughout the mammalian nervous system is indicated.

UN IDs	UN 2811 6.1 / PGIII
HS Code	29349990

Last Update：2024-01-02 23:10:35

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Product Name: JZL 184 Visit Supplier Webpage Request for quotation
CAS: 1101854-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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JZL 184

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